| Project/Area Number |
24890190
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Yokohama City University |
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Principal Investigator |
MAESHIMA Hanae 横浜市立大学, 医学(系)研究科(研究院), 客員研究員 (80638172)
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| Research Collaborator |
UCHIMOTO Kazuhiro 横浜市立大学, 医学部, 助教 (50710951)
ANDOH Tomio 横浜市立大学, 医学研究科, 客員教授 (00193110)
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| Project Period (FY) |
2012-08-31 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | エリスロポエチン / マンニトール / 新生児 / 神経保護 / 神経細胞死 / 麻酔薬 / 吸入麻酔 / アポトーシス / 幼弱動物 / 海馬 / 吸入麻酔薬 / 幼若動物 |
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| Research Abstract |
General anesthetics are shown to induce wide spread apoptosis in the developing brain. We studied if mannitol - erythropoietin (M-Epo) combined administration affords protection against anesthetic-induced neurotoxicity in neonatal rats. We found that Caspase-3 was induced in the cerebral cortex and hippocampus after 6 hour exposure to general anesthetics, meaning apoptosis increasing. Intraperitoneal administration of mannitol and Epo failed to inhibit apoptosis. In anesthetized rats, blood saturation of oxygen did not decreased, but blood concentration of carbon dioxide increased. Our results cannot suggest whether M-Epo is effective or not in inhibiting anesthetic-induced neurotoxicity in immature brain.
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