Development of an index for evaluating the pressure ulcer healing process via fibronectin degradation products in the pressure ulcer wound surface

Research Project

Project/Area Number	24890192
Research Category	Grant-in-Aid for Research Activity Start-up
Allocation Type	Single-year Grants
Research Field	Fundamental nursing
Research Institution	Mie Prefectural College of Nursing
Principal Investigator	MATSUMOTO hisako 三重県立看護大学, 看護学部, 講師 (40454376)
Project Period (FY)	2012-08-31 – 2014-03-31
Project Status	Completed (Fiscal Year 2013)
Budget Amount *help	¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000) Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000) Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords	褥瘡 / フィブロネクチン / 創傷治癒過程
Research Abstract	The diversity of pressure ulcers makes it difficult to determine what stage they are at during the healing process. In this study, protein was extracted from gauze that had been applied to the wound surface of pressure ulcers, and the analysis was focused on fibronectin (FN) molecules, which play an important role in the wound-healing process. Results indicated that, when granulation tissue is in a favorable state, FN and N-terminal domain segments decrease, and when the wound surface has a tendency to dry, the amount of N-terminal domain segments does not have a tendency to be affected. This suggested that FN may affect the healing process of pressure ulcers .