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Development of the novel biomarker for tissue damage using polyamines and their metabolites

Research Project

Project/Area Number 24890195
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Legal medicine
Research InstitutionKyoto Prefectural University of Medicine

Principal Investigator

UEMURA Takeshi  京都府立医科大学, 医学(系)研究科(研究院), 助教 (50401005)

Project Period (FY) 2012-08-31 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywordsポリアミン / アクロレイン / 肝臓 / アルコール / アセトアルデヒド / スペルミン酸化酵素 / エタノール / バイオマーカー
Research Abstract

The objective of this research is to develop a novel test for the identification of the cause of death in legal autopsy cases. We found that alcohol consumption induced spermine oxidase (SMO) at the transcriptional level in the liver and generated acrolein by polyamine metabolism to exert cytotoxicity. Our results indicate that polyamines and acrolein levels in liver tissues can be used as a novel biomarker for tissue damage caused by alcohol consumption.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • Research Products

    (13 results)

All 2013 Other

All Journal Article (2 results) (of which Peer Reviewed: 1 results) Presentation (8 results) (of which Invited: 1 results) Remarks (3 results)

  • [Journal Article] Acetaldehyde-induced cytotoxicity involves induction of spermine oxidase at the transcriptional level2013

    • Author(s)
      Uemura T., Tanaka Y., Higashi K., Miyamori D., Takasaka T., Nagano T., Toida T., Yoshimoto K., Igarashi K., and Ikegaya H
    • Journal Title

      Toxicology

      Volume: 310C Pages: 1-7

    • Related Report
      2013 Final Research Report
  • [Journal Article] Acetaldehyde-induced cytotoxicity involves induction of spermine oxidase at the transcriptional level.2013

    • Author(s)
      Uemura, T. et al.
    • Journal Title

      Toxicology

      Volume: 310 Pages: 1-7

    • DOI

      10.1016/j.tox.2013.05.008

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] Acetaldehyde-induced cytoxicity involves induction of spermine oxidase at the transcrptional level2013

    • Author(s)
      Uemura T, Tanaka Y, Higashi K, Miyamori D, Takasaka T, Nagano T, Toida T, Yoshimoto K, Igarashi K, and Ikegaya H
    • Organizer
      Gordon Research Conference on Polyamines 2013
    • Related Report
      2013 Final Research Report
  • [Presentation] アセトアルデヒドの肝細胞毒性には,スペルミンオキシダーゼが関与する2013

    • Author(s)
      植村武史,高坂友和,宮森大輔,吉本寛司,池谷 博
    • Organizer
      第97次日本法医学会学術全国集会
    • Place of Presentation
      札幌
    • Related Report
      2013 Annual Research Report
  • [Presentation] Acetaldehyde-induced ccytoxicity involves induction of spermine oxidase at the transcrptional level2013

    • Author(s)
      Uemura T*, Tanaka Y, Higashi K, Miyamori D, Takasaka T, Nagano T, Toida T, Yoshimoto K, Igarashi K, and Ikegaya H
    • Organizer
      Gordon Research Conference on Polyamines 2013
    • Place of Presentation
      New Hampshire, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] Regulation of cellular polyamines by transport, protein sorting and metabolism2013

    • Author(s)
      Uemura T, Stringer DE, Blohm-Mangone KA, Ikegaya H, Gerner EW
    • Organizer
      第86回日本生化学会
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] アセトアルデヒドは、スペルミンオキシダーゼを転写レベルで誘導する2013

    • Author(s)
      植村 武史
    • Organizer
      日本ポリアミン学会第4回大会
    • Place of Presentation
      仙台
    • Related Report
      2012 Annual Research Report
  • [Presentation] アセトアルデヒドは,スペルミンオキシダーゼを転写レベルで誘導する

    • Author(s)
      植村武史,東恭平,戸井田敏彦,五十嵐一衛,池谷博
    • Organizer
      日本ポリアミン学会第4回年会
    • Related Report
      2013 Final Research Report
  • [Presentation] Regulation of cellular polyamine levels by transport, protein sorting and metabolism

    • Author(s)
      Uemura T., Stringer D.E., Blohm-Mangone K., Gerner E.W
    • Organizer
      第86回日本生化学大会
    • Related Report
      2013 Final Research Report
  • [Presentation] アセトアルデヒドの肝細胞毒性には,スペルミンオキシダーゼが関与する

    • Author(s)
      植村武史,高坂友和,宮森大輔,吉本寛司,池谷博
    • Organizer
      第97次日本法医学会学術全国集会
    • Related Report
      2013 Final Research Report
  • [Remarks]

    • URL

      http://www.f.kpu-m.ac.jp/k/hoi/

    • Related Report
      2013 Final Research Report
  • [Remarks] 京都府立医科大学法医学教室

    • URL

      http://www.f.kpu-m.ac.jp/k/hoi/

    • Related Report
      2013 Annual Research Report
  • [Remarks] 京都府立医科大学 法医学教室

    • URL

      http://www.f.kpu-m.ac.jp/k/hoi/

    • Related Report
      2012 Annual Research Report

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Published: 2012-11-27   Modified: 2019-07-29  

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