Research Project
Grant-in-Aid for Research Activity Start-up
We showed that a new neurite arise from a cell body and becomes a new axon after axotomy in hippocampal neurons in dissociated culture and retrograde transport of phosphorylated stat3 (p-stat3) by importin-dynein complex contributes to inducing the neuritogenesis after axtomy in our previous reports. In this time, we tried to show the retrograde transport of p-stat3 contributes to inducing reconstruction and plasticity of neural network in motor cortex in vivo by using spinal cord injury model rat. We showed that the level of p-stat3 increased after spinal cord injury in not only the injury site but also the rostral site to the injury site by Western blotting. This result suggested that p-stat3 was transported by retrograde axonal transport after spinal cord injury. But further studies are required to show whether the retrograde transport of p-stat3 contributes to inducing reconstruction and plasticity of neural network in motor cortex.
All 2013
All Presentation (2 results)
