Retrograde axonal transport contributes to neural plasticity in motor cortex after spinal cord injury
| Project/Area Number |
24890198
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Neurology
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
OHARA RYO 京都府立医科大学, 医学(系)研究科(研究院), 助教 (80636986)
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| Project Period (FY) |
2012-08-31 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 脊髄損傷後 / 逆行性軸索輸送 / 神経回路の可塑性 / 脊髄損傷 / 神経回路の再構築 / retrograde tracer |
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| Research Abstract |
We showed that a new neurite arise from a cell body and becomes a new axon after axotomy in hippocampal neurons in dissociated culture and retrograde transport of phosphorylated stat3 (p-stat3) by importin-dynein complex contributes to inducing the neuritogenesis after axtomy in our previous reports. In this time, we tried to show the retrograde transport of p-stat3 contributes to inducing reconstruction and plasticity of neural network in motor cortex in vivo by using spinal cord injury model rat. We showed that the level of p-stat3 increased after spinal cord injury in not only the injury site but also the rostral site to the injury site by Western blotting. This result suggested that p-stat3 was transported by retrograde axonal transport after spinal cord injury. But further studies are required to show whether the retrograde transport of p-stat3 contributes to inducing reconstruction and plasticity of neural network in motor cortex.
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Report
(3 results)
Research Products
(2 results)
