| Project/Area Number |
24890200
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
OGAWA SATORU 京都府立医科大学, 医学部附属病院, 助教 (50636131)
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| Project Period (FY) |
2012-08-31 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 血栓 / 止血 / 人工心肺 / フローチャンバー / 血流 / 血小板 / 抗凝固薬 / 人工心肺手術 |
|---|
| Research Abstract |
After cardiopulmonary bypass (CPB) surgery, platelet concentration is the mainstay approach for hemostasis. The cut-off value and its monitoring, however, are not established in clinical practice. This study is conducted to investigate the interaction between platelet number and platelet function in the blood flow. In result, CPB caused the depletion in platelet count after hemodilution and inhibition of platelet function. We also observed the anticonagulants affect platelet thrombus formation by low thrombin generation on thrombus surface in flow condition. In conclusion, blood flow should be included on the development of novel monitoring apparatus for the perioperative bleeding.
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