Direct reprogramming of functional human osteoblasts for periodontal tissue regeneration
| Project/Area Number |
24890201
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
YAMAMOTO Kenta 京都府立医科大学, 医学研究科, 助教 (00636160)
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| Project Period (FY) |
2012-08-31 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 再生医療 / 骨芽細胞 / ダイレクト・リプログラミング |
|---|
| Research Abstract |
Alveolar bone resorption associated with advanced periodontitis causes tooth loss and reduces quality of life (QOL). Transplantation of autologous osteoblasts into periodontal tissue may facilitate alveolar bone regeneration as a new cell therapy. In this study, we attempted to directly reprogram human somatic cells into osteoblast-like cells by transducing some transcription factor genes. ALP positive cells were induced from somatic cells at a high efficiency, and the resultant cells expressed osteoblast-specific factors and produced mineralized bone matrix. Moreover, the resultant cells displayed a similar gene expression profile as normal human osteoblasts. These findings suggest successful reprogramming of somatic cells directly into osteoblasts, which may provide new regenerative medicine for periodontal diseases.
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Report
(3 results)
Research Products
(10 results)
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[Journal Article] Marfan's syndrome : Clinical manifestations in the oral-craniofacial area, biophysiological roles of fibrillins and elastic extracellular microfibers, and disease control of the fibrillin gene2013
Author(s)
Nishikawa T, Yamamoto T, Honjo K, Ichioka H, Yamamoto K, Kanamura N, Kato H, Wato M, Kubo T, Mori M, Tanaka A. Asian J
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Journal Title
Oral Maxillofac Surg
Volume: 25
Pages: 374-388
Related Report
Peer Reviewed
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[Journal Article] Marfan's syndrome: Clinical manifestations in the oral-craniofacial area, biophysiological roles of fibrillins and elastic extracellular microfibers, and disease control of the fibrillin gene2013
Author(s)
Nishikawa T, Yamamoto T, Honjo K, Ichioka H, Yamamoto K, Kanamura N, Kato H, Wato M, Kubo T, Mori M, Tanaka A.
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Journal Title
Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology
Volume: 25
Issue: 4
Pages: 374-388
DOI
Related Report
Peer Reviewed
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