| Project/Area Number |
24890207
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Human pathology
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
IKURA Yoshihiro 和歌山県立医科大学, 医学部, その他 (00240953)
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| Project Period (FY) |
2012-08-31 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 非アルコール性脂肪性肝疾患 / 酸化ストレス / ユビキチン / スカベンジャー受容体 / 酸化リン脂質 / 腫瘍壊死因子 / マクロファージ / 炎症性サイトカイン / 過酸化脂質 / 診断基準 / マロリー・デンク小体 |
|---|
| Research Abstract |
Although oxidative stress is recognized to contribute to the development and progression of nonalcoholic fatty liver disease (NAFLD), detailed pathologic mechanisms are still obscure. Ballooning degeneration, which is considered to be a manifestation of oxidative injury, is required for diagnosis of nonalcoholic steatohepatitis (NASH). However, identification of ballooned hepatocytes is not easy even for expert pathologists. The present study indicated usefulness of ubiquitin immunostaining as a complementary diagnostic tool for NASH/NAFLD. Furthermore, in liver specimens diagnosed as NASH/NAFLD correctly by this diagnostic procedure, a close association between macrophage scavenger receptor-mediated oxidized phospholipid accumulation and tumor necrosis factor alpha production in macrophage was shown immunohistochemically. The result suggests a possibility that a vicious circle of oxidative stress is formed in livers of NASH/NAFLD.
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