| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
Increasing evidences indicate that inflammation is involved in various aspects of metabolic disease. In this process, inflammasome plays critical role to initiate inflammatory response by activation of caspase-1. To investigate the novel regulatory mechanisms of inflammasome, I examined the role of CARD-only proteins (COPs) which are known as homologs of caspase-1. I identified that CARD16 exhibits higher expression levels than other COPs in human peripheral blood mononuclear cells. Furthermore, functional analysis in transfected HeLa cells revealed that oligomerization activity allows CARD16 to function as a caspase-1 activator. These results suggest CARD16 might promote inflammatory response by activation of caspase-1 and subsequent interleukin-1 β release.
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