Elucidation of the mechanism of cerebral blood flow based on redox regulation
| Project/Area Number |
24890225
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|---|
| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Biological pharmacy
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| Research Institution | Kumamoto University (2013)
Kitasato University (2012) |
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Principal Investigator |
KURAUCHI Yuki 熊本大学, 大学院先導機構, 助教 (70631638)
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| Project Period (FY) |
2012-08-31 – 2014-03-31
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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|---|
| Keywords | レドックス / 脳循環 / 神経-グリア-血管相互作用 / レドックスシグナル / 薬理学 / 一酸化窒素 |
|---|
| Research Abstract |
The purpose of this study is to elucidate the mechanism of cerebral blood flow (CBF) based on redox regulation and search for the candidate medicine which improves CBF. In this study, the following was clarified.1) L-Citrulline improved the decrease in CBF during cortical spreading depression (CSD) via activation of nitric oxide (NO) signaling pathway.2) Activation of both MEK/ERK signaling pathway and calcineurin/NFAT signaling pathway contributes to the unusual increase in CBF and neuronal cell death induced by N-methyl-D-aspartate (NMDA).
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Report
(3 results)
Research Products
(56 results)
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[Book] 実験医学2012
Author(s)
香月博志 (分担執筆)
Total Pages
217
Publisher
羊土社
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