Exploring a novel cardiomyocyte cell cycle regulator by utilizing a fluorescent ubiquitination-based cell cycle indicator
Project/Area Number |
24890227
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Research Category |
Grant-in-Aid for Research Activity Start-up
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Allocation Type | Single-year Grants |
Research Field |
Pathological medical chemistry
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Research Institution | Keio University |
Principal Investigator |
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Project Period (FY) |
2012-08-31 – 2014-03-31
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Project Status |
Completed (Fiscal Year 2013)
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Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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Keywords | 細胞周期 / ライブイメージング / 心臓発生 / 再生医療 / 心筋再生 / 心不全 |
Research Abstract |
The minimal capacity of mature cardiomyocte regeneration is one of the factors which determines the poor prognosis of heart failure. If we can proliferate cardiomyocytes and regenerate the heart, we will be able to completely cure heart failure. We planned to explore a novel cardiomyocyte cell cycle regulator by utilizing a fluorescent ubiquitination-based cell cycle indicator. We identified a protein which the expression level changes during the proliferation phase of cell cycle. We are analyzing the function of this candidate protein by over-expressing and deleting it in cardiomyocyte.
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Report
(3 results)
Research Products
(4 results)
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[Journal Article] Time-lapse imaging of cell cycle dynamics during development in living cardiomyocyte.2014
Author(s)
Hashimoto H, Yuasa S, Tabata H, Tohyama S, Hayashiji N, Hattori F, Muraoka N, Egashira T, Okata S, Yae K, Seki T, Nishiyama T, Nakajima K, Sakaue-Sawano A, Miyawaki A and Fukuda K.
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Journal Title
J.Mol. Cell. Cardiol.
Volume: S0022-2828(14)
Pages: 97-2
DOI
Related Report
Peer Reviewed
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