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Exploring a novel cardiomyocyte cell cycle regulator by utilizing a fluorescent ubiquitination-based cell cycle indicator

Research Project

Project/Area Number 24890227
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Pathological medical chemistry
Research InstitutionKeio University

Principal Investigator

HASHIMOTO Hisayuki  慶應義塾大学, 医学部, 助教 (90528390)

Project Period (FY) 2012-08-31 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords細胞周期 / ライブイメージング / 心臓発生 / 再生医療 / 心筋再生 / 心不全
Research Abstract

The minimal capacity of mature cardiomyocte regeneration is one of the factors which determines the poor prognosis of heart failure. If we can proliferate cardiomyocytes and regenerate the heart, we will be able to completely cure heart failure. We planned to explore a novel cardiomyocyte cell cycle regulator by utilizing a fluorescent ubiquitination-based cell cycle indicator. We identified a protein which the expression level changes during the proliferation phase of cell cycle. We are analyzing the function of this candidate protein by over-expressing and deleting it in cardiomyocyte.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • Research Products

    (4 results)

All 2014 2013 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (2 results)

  • [Journal Article] Time-lapse imaging of cell cycle dynamics during development in living cardiomyocyte.2014

    • Author(s)
      Hashimoto H, Yuasa S, Tabata H, Tohyama S, Hayashiji N, Hattori F, Muraoka N, Egashira T, Okata S, Yae K, Seki T, Nishiyama T, Nakajima K, Sakaue-Sawano A, Miyawaki A and Fukuda K.
    • Journal Title

      J.Mol. Cell. Cardiol.

      Volume: S0022-2828(14) Pages: 97-2

    • DOI

      10.1016/j.yjmcc.2014.03.020

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Time-lapse imaging of cell cycle dynamics during development in living cardiomyocyte2014

    • Author(s)
      Hisayuki Hashimoto
    • Journal Title

      Journal of Molecular and Cellular Cardiology

      Volume: 印刷中

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] A Novel Cardiac ex vivo Culture System Revealed the Elongation of Cell Cycle Phases in Cardiomyocytes During Development2013

    • Author(s)
      Hisayuki Hashimoto, Shinsuke Yuasa, Hidenori Tabata, Shugo Tohyama, Toru Egashira, Tomohisa Seki, Kazunori Nakajima, Keiichi Fukuda
    • Organizer
      第30回国際心臓研究学会日本部会総会
    • Place of Presentation
      米国・サンディエゴ
    • Year and Date
      2013-06-29
    • Related Report
      2013 Final Research Report
  • [Presentation] A Novel Cardiac ex vivo Culture System Revealed the Elongation of Cell Cycle Phases in Cardiomyocytes During Development

    • Author(s)
      Hisayuki Hashimoto
    • Organizer
      International Society for Heart Research (ISHR) The 30 th Annual Meeting of the International Society for Heart Research Japanese Section
    • Place of Presentation
      San Diego, USA
    • Related Report
      2013 Annual Research Report

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Published: 2012-11-27   Modified: 2019-07-29  

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