ER stress and presbycusis

Research Project

Project/Area Number	24890231
Research Category	Grant-in-Aid for Research Activity Start-up
Allocation Type	Single-year Grants
Research Field	Otorhinolaryngology
Research Institution	Keio University
Principal Investigator	OISHI Naoki 慶應義塾大学, 医学部, 講師 (10348740)
Project Period (FY)	2012-08-31 – 2014-03-31
Project Status	Completed (Fiscal Year 2013)
Budget Amount *help	¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000) Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords	内耳生化学 / 加齢性難聴 / 小胞体ストレス
Research Abstract	We tried to treat presbycusis by giving a ER stress-blocker, TUDCA, to different two types of mice. Presbycusis in one type of mice is promoted by progressive loss of auditory hair cells, which was not able to be attenuated by administratin of TUDCA. On the other hand, presbysis in the other type of mice which is promoted partly by loss of spiral ganglion cells was statistically significantly prevented by long-term continueous administration of TUDCA. The results were suggestive of future possibility of attenuating presbycusis by reducing ER stress.