Molecular mechanisms of amyloid beta metabolism by a cell survival factor
Project/Area Number |
24890236
|
Research Category |
Grant-in-Aid for Research Activity Start-up
|
Allocation Type | Single-year Grants |
Research Field |
Neurology
|
Research Institution | Sophia University |
Principal Investigator |
|
Project Period (FY) |
2012-08-31 – 2014-03-31
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
Keywords | アルツハイマー病 / アミロイドベータ / 生理活性分子 / シグナル伝達 / 脳神経疾患 |
Research Abstract |
Alzheimer's disease (AD) is the most common cause of dementia. Humanin (HN) is a novel neuroprotective factor and suppresses the neuronal death caused by AD-related insults in test tubes. A highly potent HN derivative ameliorated cognitive deficits and sustained the increase of amyloid burden in an AD mouse model, which exhibits complex AD-relevant pathology. In this study, we investigated the molecular mechanisms how HN suppresses amyloid accumulation, particularly focusing on an amyloid degradation enzyme and amyloid clearance by glial cells.
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Report
(3 results)
Research Products
(8 results)