Analysis of impact of blood metabolizing enzymes on the prediction brain blood concentration in midazolam sedation
| Project/Area Number |
24890241
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Surgical dentistry
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| Research Institution | Showa University |
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Principal Investigator |
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| Project Period (FY) |
2012-08-31 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 静脈内鎮静法 / プロポフォール / ミダゾラム / レミフェンタニル / 異常絞扼反射 / TCI機能 |
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| Outline of Final Research Achievements |
Excessive gagging reflex precludes dental treatment. Such patients need to sedate during treatment, though; patients are still resistant to the treatment even under sedation. Remifentanil(RF) is a short acting opiate, strongly suppressing reflex. We have tried to apply this agent to the patients with strong gagging reflex.
Six patients who had been resistant to suppression of gagging reflex by using midazolam(M) and propofol(P) were enrolled. Six patients were treated under sedation by using (P) and (RF). Treatments on the former sedation were unsuccessful, and all the latter sedation were successful. The treatment providers were satisfied with the smoothness of the treatment. (RF) there is a report that was effective in suppressing abnormal strangulation reflected by the combination with (P) or (M) I was applied to the intravenous sedation. Although amnesic effect was attenuated by reduction of (P), they tended not to affect much to the satisfaction of the patient.
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Report
(3 results)
Research Products
(1 results)
