| Project/Area Number |
24890255
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Bacteriology (including Mycology)
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| Research Institution | Tokyo University of Pharmacy and Life Science |
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Principal Investigator |
TADA RUI 東京薬科大学, 薬学部, 助教 (70635888)
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| Project Period (FY) |
2012-08-31 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | リポソーム / 多糖 / 粘膜免疫 / 全身免疫 / 真菌症 / 粘膜ワクチン / 粘膜アジュバント / 細胞壁多糖 / ワクチン / 核酸医薬 |
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| Research Abstract |
Our laboratory has long been working on the liposomes with respect to immunological approaches. In the course of our study, we have already found that a nasal administration of the cationic liposomes with protein antigens dramatically enhanced both antigen-specific mucosal and systemic immune responses, namely the cationic liposome acts as a potent mucosal adjuvant in mice. In this study, we examined mucosal adjuvant activity of the cationic liposome against fungal polysaccharide antigens in order to overcome fungal infections. We first prepared polysaccharide antigens-encapsulated cationic liposomes, and then DBA/2 or BALB/c mice were immunized intranasally once a week with polysaccharide antigen-encapsulated cationic liposomes. Our study shows that intranasal vaccination with the polysaccharide antigen-encapsulated cationic liposomes significantly exerted polysaccharide antigen-specific antibody productions in DBA/2 mice, but not in BALB/c mice.
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