Referred pain in the oral and maxillofacial area occurs in heart disease

• Project/Area Number: 24890262
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Surgical dentistry
• Research Institution: The Nippon Dental University
• Principal Investigator: IDE Ryoji 日本歯科大学, 生命歯学部, 助教 (10638084)
• Project Period (FY): 2012-08-31 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 関連痛 / 心疾患 / TRPV1 / ナトリウムチャネル / 篩状神経節 / 三叉神経節

Research Abstract

Firstly, we developed a procedure and became able to obtain a steadily number of neurons from acutely isolated and cultured immature rat nodose ganglion (NG).
Next, using electrophysiological technique, we targeted small NG neurons possessed tetrodotoxin resistant (TTX-R) voltage-gated sodium channels and investigated whether excitement occurs at acutely applied capsaicin on the neurons. The results showed that action potential could be induced by the capsaicin treatment in 72% of the neurons. We examined.

Research Products

• [Journal Article] Role of rostral medulla in serotonin-induced changes of respiratory rhythm in newborn rat brainstem-spinal cord preparations (2014)
  • Author(s): Makino M, Saiki C, Ide R, Matsumoto S
  • Journal Title: Neurosci Lett Volume: 559 Pages: 127-131
• [Journal Article] Role of rostral medulla in serotonin-induced changes of respiratory rhythm in newborn rat brainstem-spinal cord preparations. (2014)
  • Author(s): Makino M, Saiki C, Ide R, Matsumoto S.
  • Journal Title: Neurosci Letters Volume: 559 Pages: 127-131
  • DOI: 10.1016/j.neulet.2013.12.002
  • Peer Reviewed
• [Presentation] Capsaicin sensitivities of neonatal rat nodose ganglion neurons under TTX application (2014)
  • Author(s): Ide R, Tamiya J, Kanazawa T, Takahashi M, Saiki C, Matsumoto S
  • Organizer: 第90回日本生理学会大会
  • Place of Presentation: 東京
  • Year and Date: 2014-03-29
• [Presentation] Immunohistochemical analysis of Nav1.9 sodium channel and transient receptor potential ankyrin 1 (TRPA1) in newborn rat large intestine enteric nervous system (2014)
  • Author(s): Saiki C, Ide R, Tamiya J, Matsumoto S
  • Organizer: 第91回日本生理学会大会
  • Place of Presentation: 鹿児島大学 郡元キャンパス
• [Presentation] Immunohistochemical analysis of Nav1.9 sodium channel and transient receptor potential ankyrin 1 (TRPA1) in newborn rat large intestine enteric nervous system (2013)
  • Author(s): Saiki C,Ide R,Tamiya J,Matsumoto S
  • Organizer: 第91回日本生理学会大会
  • Place of Presentation: 鹿児島
  • Year and Date: 2013-03-17
• [Presentation] 新生仔ラット篩状神経節ニューロンのテトロドトキシン投与下におけるカプサイシン感受性について (2013)
  • Author(s): 井出 良治
  • Organizer: 第90回日本生理学会大会
  • Place of Presentation: タワーホール船堀(東京）