| Project/Area Number |
24890292
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Gunma Institute of Public Health and Environmental Sciences |
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Principal Investigator |
MATSUMOTO Naoki 群馬県衛生環境研究所, 研究企画係, 研究員 (80631514)
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| Project Period (FY) |
2012-08-31 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 小児先天性心疾患 / 心筋保護効果 / β遮断薬 / ランジオロール / βブロッカー / 先天性心疾患 / 経食道心エコー / 再灌流障害 / 心臓手術 / サイトカイン |
|---|
| Research Abstract |
In children with congenital heart disease patients who were scheduled for a cardiac surgery under cardio-pulmonary bypass, myocardial damage markers, cytokines, cardiac function, prognostic factors between the two groups of landiolol administration group and non-administration group, the myocardial protective effect of beta-blocker, landiolol, were compared.
In landiolol administration group, increase of cytokines and myocardial damage marker were tended to be suppressed, cardiac function was also well maintained after surgery. In addition, post-operative hospital stay and intensive care unit admission period tended to be shortened in landiolol group.
Administration of landiolol in the perioperative period possibly improves the prognosis for the patients with the congenital heart disease by the myocardial protective effect.
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