The mechanism of aberrant gene expressions in adulthood caused by fetal and neonatal nutrition status.

Research Project

Project/Area Number	24890299
Research Category	Grant-in-Aid for Research Activity Start-up
Allocation Type	Single-year Grants
Research Field	Obstetrics and gynecology
Research Institution	National Research Institute for Child Health and Development
Principal Investigator	TOMOKO Kawai 独立行政法人国立成育医療研究センター, 周産期病態研究部, 研究員 (40423404)
Project Period (FY)	2012-08-31 – 2014-03-31
Project Status	Completed (Fiscal Year 2013)
Budget Amount *help	¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000) Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords	エピゲノム / DNAメチル化 / 胎盤 / ヒト胎盤 / 栄養 / エピジェネティックス / 周産期
Research Abstract	In this study, we focused on human placental epigenetic regulation which might be affected by fetal growth restriction or gestational maternal weight gain. As a result, inadequate gestational weight gain augmented randomicity at epigenetic regulations even in placentas from normal birth weight. Furthermore, it is suggested that fetal growth restriction caused non-uniformity in epigenetic status independent from gestational weight gain.