| Project/Area Number |
24890299
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | National Research Institute for Child Health and Development |
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Principal Investigator |
TOMOKO Kawai 独立行政法人国立成育医療研究センター, 周産期病態研究部, 研究員 (40423404)
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| Project Period (FY) |
2012-08-31 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | エピゲノム / DNAメチル化 / 胎盤 / ヒト胎盤 / 栄養 / エピジェネティックス / 周産期 |
|---|
| Research Abstract |
In this study, we focused on human placental epigenetic regulation which might be affected by fetal growth restriction or gestational maternal weight gain. As a result, inadequate gestational weight gain augmented randomicity at epigenetic regulations even in placentas from normal birth weight. Furthermore, it is suggested that fetal growth restriction caused non-uniformity in epigenetic status independent from gestational weight gain.
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