| Project/Area Number |
24890300
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Obstetrics and gynecology
|
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| Research Institution | National Research Institute for Child Health and Development |
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Principal Investigator |
FUKUDA Atsushi 独立行政法人国立成育医療研究センター, その他部局等, 研究員 (00638091)
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|---|
| Project Period (FY) |
2012-08-31 – 2014-03-31
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | エピジェネティクス / 発生・分化 / エピゲノム / 初期胚 / トランスクリプトーム / リプログラミング / 生殖 / 全能性 |
|---|
| Research Abstract |
Loss of some epigenetic asymmetries in mouse zygote does not affect development to blastocyst. However, it causes disruption of proper expression in some developmental genes at the stage. Moreover, in vivo developmental ability in the embryos with epigenetic modifier is markedly affected under a given set of conditions. These results show that maintenance of proper epigenomic asymmetry is essential for development, implying that disruption of epigenomic asymmetry might cause recurrent miscarriage.
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