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Investigation of the mechanism responsible for the modulation of myosin heavy chain expression in muscle fibers.

Research Project

Project/Area Number 24890301
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Environmental physiology (including Physical medicine and Nutritional physiology)
Research InstitutionJapan Aerospace Exploration Agency

Principal Investigator

OHIRA Takashi  独立行政法人宇宙航空研究開発機構, 有人宇宙ミッション本部, 宇宙航空プロジェクト研究員 (40633532)

Project Period (FY) 2012-08-31 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords骨格筋 / タンパク質発現調節
Research Abstract

Gravitational unloading causes a shift of fiber phenotype toward fast-twitch type in soleus muscle. However some fibers are remain slow-twitch type. It has not known why the transformation of myosin heavy chain (MHC) phenotype is induced only in specific fibers expressing type I MHC originally. The current study was performed to investigate the effects of mechanical and/or neural factors on the fiber phenotype. Responses of MHC expression in soleus muscles to 2-week inhibition of mechanical activity or neural activity by hindlimb suspension or ablation of sciatic nerve respectively, were studied in rats. As a result, both experimental model was induced the increase of the type II MHC mRNA and protein expression. And the % distribution of fibers co-expressing type I and II MHC was increased. But fibers expressing pure type I MHC were still noted. It was suggested that the cause for de novo expression of type II MHC might be regulated by mechanical and neural activity and other factors.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report

URL: 

Published: 2012-11-27   Modified: 2019-07-29  

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