| Project/Area Number |
24890302
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Public health/Health science
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| Research Institution | Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology |
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Principal Investigator |
TANIGUCHI YU 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究員 (40636578)
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| Project Period (FY) |
2012-08-31 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 認知機能低下 / アポリポタンパクE遺伝子多型 / 身体機能 / 栄養状態 / 遺伝子多型 / MMSE / 日本語版MoCA |
|---|
| Research Abstract |
396 adults were reevaluated cognitive function during 1-year period, and cognitive decline was defined as decrease of two points or more on the Mini-Mental State Examination (MMSE) during follw-up. No significant difference was observed among APOE4 allele and cognitive decline. Gait function (maximum gait speed, step length) and nutritional biomarker (RBC,Alb,HDL-C) showed linear associations for cognitive decline after controlling for APOE4 allele and important confounders. Our findings indicate that APOE4 allele was not a risk marker of subsequent cognitive decline, and not a potential confounding variable between gait function or nutritional biomarker and cognitive decline.
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