Research Project
Grant-in-Aid for Research Activity Start-up
Aldosterone which regulates blood pressure is produced by angiotensin II (A-II) in zona glomerulosa of adrenal cortex. We previously demonstrated that the metabolite of A-II negatively regulated A-II mediated aldosterone production in human adrenocortical cancer cell line. In this study, we clarified that the metabolite was angiotensin 1-7 and it inhibit aldosterone production after A-II stimulation. The function of angiotensin 1-7 on aldosterone production was mediated by MAS receptor. We showed a new aldosterone production machinery via MAS receptor and our results might be useful for new target of anti-hypertensive agents.
All 2014 2013 2012 Other
All Journal Article (11 results) (of which Peer Reviewed: 11 results) Presentation (6 results) (of which Invited: 1 results)
Endocrinology
Volume: 155 Pages: 47-55
Volume: 154 Pages: 214-21
Clin Endocrinol (Oxf)
Volume: 79 Pages: 617-22
Volume: 155 Issue: 1 Pages: 47-55
10.1210/en.2013-1733
Exp Clin Endocrinol Diabetes
Volume: 120 Pages: 244-7
Volume: 153 Pages: 1774-82
Volume: 153 Pages: 4228-35
Volume: 153 Issue: 4 Pages: 1774-1782
10.1210/en.2011-1733
Volume: 153 Issue: 9 Pages: 4328-4335
10.1210/en.2012-1241
Volume: 120 Issue: 04 Pages: 244-247
10.1055/s-0032-1301896
Volume: 154(1): Issue: 1 Pages: 214-21
10.1210/en.2012-1557