| Project/Area Number |
24H00489
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Review Section |
Medium-sized Section 37:Biomolecular chemistry and related fields
|
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| Research Institution | The University of Tokyo |
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Principal Investigator |
キャンベル ロバート.アール 東京大学, 大学院理学系研究科(理学部), 教授 (40831318)
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| Co-Investigator(Kenkyū-buntansha) |
寺井 琢也 東京大学, 大学院理学系研究科(理学部), 准教授 (00508145)
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| Project Period (FY) |
2024-04-01 – 2027-03-31
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| Project Status |
Granted (Fiscal Year 2025)
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| Budget Amount *help |
¥48,750,000 (Direct Cost: ¥37,500,000、Indirect Cost: ¥11,250,000)
Fiscal Year 2025: ¥12,090,000 (Direct Cost: ¥9,300,000、Indirect Cost: ¥2,790,000)
Fiscal Year 2024: ¥24,570,000 (Direct Cost: ¥18,900,000、Indirect Cost: ¥5,670,000)
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| Keywords | Fluorescence / Cell Signaling / Bioimaging / Biosensor / Protein Engineering |
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| Outline of Research at the Start |
Fluorescent protein (FP)-based sensors are powerful tools that enable researchers to visualize biological processes in cells and organisms. We have pioneered methods to accelerate the development and optimization of new FP-based sensors. We now propose to use these methods to create a series of new high-performance sensors for important biomolecules, expand the color range into the near-infrared (NIR) region, and create sensors that “integrate” biological signals over time. This work will massively expand the target palette, the color palette, and the sensing mechanisms, of FP-based sensors.
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