| Project/Area Number |
24H00569
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Review Section |
Medium-sized Section 44:Biology at cellular to organismal levels, and related fields
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| Research Institution | Kyoto University |
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Principal Investigator |
ALEV CANTAS 京都大学, 高等研究院, 教授 (30726477)
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| Project Period (FY) |
2024-04-01 – 2029-03-31
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| Project Status |
Granted (Fiscal Year 2024)
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| Budget Amount *help |
¥47,710,000 (Direct Cost: ¥36,700,000、Indirect Cost: ¥11,010,000)
Fiscal Year 2024: ¥10,270,000 (Direct Cost: ¥7,900,000、Indirect Cost: ¥2,370,000)
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| Keywords | ヒト胚発⽣ / 体外胚モデル / オルガノイド |
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| Outline of Research at the Start |
Building & extending upon our recent in vitro 3D model of human somitogenesis (axioloid) we propose to reconstitute and analyze human and non-human primate (monkey & ape) axial development in vitro. Our established axioloid v2.0 model with somites & neural tube will be extensively analyzed at the molecular & functional level, with a focus on the identification & validation of human & non-human primate-specific features associated with axial development & morphogenesis. Successful implementation of our research will enhance our still limited understanding of human & non-human primate biology.
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