Unraveling enzyme functions in liquid -liquid phase separation droplets

Research Project

Project/Area Number	24K01995
Research Category	Grant-in-Aid for Scientific Research (B)
Allocation Type	Multi-year Fund
Section	一般
Review Section	Basic Section 43040:Biophysics-related
Research Institution	Okinawa Institute of Science and Technology Graduate University
Principal Investigator	LAURINO Paola 沖縄科学技術大学院大学, タンパク質工学・進化ユニット, 准教授 (90812256)
Project Period (FY)	2024-04-01 – 2027-03-31
Project Status	Granted (Fiscal Year 2024)
Budget Amount *help	¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000) Fiscal Year 2026: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000) Fiscal Year 2025: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000) Fiscal Year 2024: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Keywords	LLPS / droplets / kinetics
Outline of Research at the Start	The study seeks to understand enzyme function within LLPS compartments, exploring properties like molecular weight and chemical reactions. Investigating enzyme inhibition in LLPS is crucial, spanning biochemistry, medicine, and biotechnology, addressing a research gap.