Exploring Suppressive Immunity Mechanisms in the Ovarian Cancer Microenvironment Using Tumor-Infiltrating T Cells

Research Project

Project/Area Number	24K02591
Research Category	Grant-in-Aid for Scientific Research (B)
Allocation Type	Multi-year Fund
Section	一般
Review Section	Basic Section 56040:Obstetrics and gynecology-related
Research Institution	Saitama Medical University
Principal Investigator	長谷川幸清埼玉医科大学, 医学部, 教授 (30534193)
Co-Investigator(Kenkyū-buntansha)	織田克利東京大学, 医学部附属病院, 教授 (30359608) 垣見和宏近畿大学, 医学部, 教授 (80273358)
Project Period (FY)	2024-04-01 – 2028-03-31
Project Status	Granted (Fiscal Year 2024)
Budget Amount *help	¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000) Fiscal Year 2027: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000) Fiscal Year 2026: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000) Fiscal Year 2025: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000) Fiscal Year 2024: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Keywords	卵巣癌 / 腫瘍微小環境 / T細部 / 免疫
Outline of Research at the Start	卵巣がんにおける抑制性免疫環境のメカニズムをTILの腫瘍応答性を指標にし、免疫細胞のサブタイプ、腫瘍微小環境などの視点から、免疫細胞学的手法および免疫ゲノム学的手法を用いて明らかにし、新規のバイオマーカーおよび免疫療法開発へと発展させる。