REDOX-Switchable Pyrazinacenes as a New Class of Near-Infrared Active Chromophores for Bio and Cellular Imaging Applications

• Project/Area Number: 24K08401
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 33010:Structural organic chemistry and physical organic chemistry-related
• Research Institution: Shibaura Institute of Technology
• Principal Investigator: RICHARDS GARY 芝浦工業大学, 工学部, 准教授 (00708620)
• Co-Investigator(Kenkyū-buntansha): 堀 顕子 芝浦工業大学, 工学部, 教授 (90433713)
• Project Period (FY): 2024-04-01 – 2027-03-31
• Project Status: Granted (Fiscal Year 2024)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2026: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2025: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2024: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: Pyrazinacenes / Azaacenes / Redox / Near Infrared emission / bioimaging

Outline of Research at the Start

REDOX-active pyrazinacenes that are able to act as sensors for redox imbalance in biological systems will be developed. REDOX-active pyrazinacenes appended with electron donor groups that are anticipated to show large redox-coupled spectral shifts (absorption/emission) will be prepared and studied.