In vivo polymer synthesis for therapeutic application via glycosylated artificial metalloenzymes

Research Project

Project/Area Number	24K08629
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Review Section	Basic Section 37030:Chemical biology-related
Research Institution	Institute of Physical and Chemical Research
Principal Investigator	張宗哲国立研究開発法人理化学研究所, 開拓研究本部, 研究員 (00774853)
Project Period (FY)	2024-04-01 – 2027-03-31
Project Status	Granted (Fiscal Year 2024)
Budget Amount *help	¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000) Fiscal Year 2026: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000) Fiscal Year 2025: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2024: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords	Artificial metalloenzyme / polymer / In vivo synthesis
Outline of Research at the Start	The aim of proposal is to develop an innovative therapeutic method based on in vivo localized polymer synthesis via glycosylated artificial metalloenzymes. The method not only avoids problems mentioned above, but also prevents unintended side effects against untargeted cells.