Role of Enhancer RNA in Switch, Suicide, and Oncogenic Recombination in B cells

Research Project

Project/Area Number	24K09325
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Review Section	Basic Section 43010:Molecular biology-related
Research Institution	Kyoto University
Principal Investigator	Begum NasimAra 京都大学, 医学研究科, 特定准教授 (80362507)
Project Period (FY)	2024-04-01 – 2027-03-31
Project Status	Granted (Fiscal Year 2024)
Budget Amount *help	¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000) Fiscal Year 2026: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000) Fiscal Year 2025: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000) Fiscal Year 2024: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords	AID / CSR / Ig / LSR / Genomic Instability
Outline of Research at the Start	Proposed research explores how enhancer RNAs from IgH locus super-enhancer control B cell recombinations, affecting antibody production and genomic stability, advancing insights into adaptive immunity's mechanisms and genomic instability.