DNAループエクストルーダーSmc5/6複合体の細胞機能の解明

• Project/Area Number: 24K09410
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 43050:Genome biology-related
• Research Institution: The University of Tokyo
• Principal Investigator: ヤポセン クリスチャン 東京大学, 定量生命科学研究所, 講師 (70985580)
• Project Period (FY): 2024-04-01 – 2027-03-31
• Project Status: Granted (Fiscal Year 2024)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2026: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2025: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2024: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: Chromosome structure / Smc5/6 / Dimer translocation

Outline of Research at the Start

To elucidate if Smc5/6 folds chromosomes, the 3D structure of the genome will be analyzed by Micro-C in budding yeast (Saccharomyces cerevisiae) cells.

Thereafter, the functional impact of Smc5/6-mediated chromosome folding on chromosome segregation and DNA repair will be analyzed.