３次元ゲノム形成の分子基盤解明及びその生物学的な意義の解析

Research Project

Project/Area Number	24K09419
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Review Section	Basic Section 43050:Genome biology-related
Research Institution	Institute of Physical and Chemical Research
Principal Investigator	SHARIF JAFAR 国立研究開発法人理化学研究所, 生命医科学研究センター, 専任研究員 (00577968)
Project Period (FY)	2024-04-01 – 2027-03-31
Project Status	Granted (Fiscal Year 2024)
Budget Amount *help	¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000) Fiscal Year 2026: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000) Fiscal Year 2025: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000) Fiscal Year 2024: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords	3次元ゲノム / DNA複製タイミング / エピゲノム / H2Bモノユビキチン化 / DNAメチル化
Outline of Research at the Start	The 3D genome is organized into distinct higher order structures such as loops, TADs and A/B compartments. Here, I will focus on A/B compartments and will elucidate the mechanisms that regulate compartmentalization and also explore the biological functions of compartments.