Dissecting Claustrum Neuronal Connections for Sleepiness

Research Project

Project/Area Number	24K09680
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Review Section	Basic Section 46030:Function of nervous system-related
Research Institution	University of Tsukuba
Principal Investigator	Kumar Deependra 筑波大学, 国際統合睡眠医科学研究機構, 助教 (20747696)
Co-Investigator(Kenkyū-buntansha)	船戸弘正筑波大学, 国際統合睡眠医科学研究機構, 客員教授 (90363118)
Project Period (FY)	2024-04-01 – 2027-03-31
Project Status	Granted (Fiscal Year 2024)
Budget Amount *help	¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000) Fiscal Year 2026: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000) Fiscal Year 2025: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000) Fiscal Year 2024: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Keywords	Sleepiness / Claustrum / Slow wave activity / Sik3 protein kinase
Outline of Research at the Start	A neural process that regulates sleepiness in mammals remains elusive. The claustrum, a subcortical nucleus that receives inputs from sleep-wake-related areas is a candidate neural site to investigate the neuronal substrate for sleepiness. I will determine whether the alternation in claustrum neuronal activity is a trait mark of sleepiness in Sleepy mice by monitoring and optogenetically controlling their activities and input connections.