Diagnostic and Therapeutic Potential of Circular RNAs in Autism Spectrum Disorder

Research Project

Project/Area Number	24K10503
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Review Section	Basic Section 51030:Pathophysiologic neuroscience-related
Research Institution	Institute of Physical and Chemical Research
Principal Investigator	Gailhouste Luc 国立研究開発法人理化学研究所, 脳神経科学研究センター, 研究員 (40848537)
Co-Investigator(Kenkyū-buntansha)	石田綾国立研究開発法人理化学研究所, 脳神経科学研究センター, チームリーダー (40424171)
Project Period (FY)	2024-04-01 – 2027-03-31
Project Status	Granted (Fiscal Year 2024)
Budget Amount *help	¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000) Fiscal Year 2026: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2025: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000) Fiscal Year 2024: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords	Circular RNAs / Brain development / Autism spectrum disorder / RNA therapeutics
Outline of Research at the Start	To investigate circRNA in ASD, we will establish tools for (i) accurate measurement of circRNAs in biological samples using specific PCR-based approaches and (ii) functional assessment of circRNAs using targeted knockdown and knock-in systems in neurons.