Simultaneous fMRI-EEG-DTI Longitudinal Recording of Functional Connectivity in Patients with Autism Spectrum Disorder

Research Project

Project/Area Number	24K10741
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Review Section	Basic Section 52030:Psychiatry-related
Research Institution	Juntendo University
Principal Investigator	桐野衛二順天堂大学, 医学部, 教授 (90276460)
Project Period (FY)	2024-04-01 – 2029-03-31
Project Status	Granted (Fiscal Year 2024)
Budget Amount *help	¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000) Fiscal Year 2028: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000) Fiscal Year 2027: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000) Fiscal Year 2026: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000) Fiscal Year 2025: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000) Fiscal Year 2024: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Keywords	Autism Spectrum Disorder / fMRI / DTI / DKI / EEG
Outline of Research at the Start	今回我々は、fMRI・脳波・拡散MRIの同時計測を行い、自閉症スペクトラム障害（Autism Spectrum Disorder: ASD）患者のFC異常を包括的かつ年齢縦断的に行い、ASDの年齢による病理変化フローの解明に重点を置く。拡散MRIとしてDKI・NODDIを用い、fMRI・脳波と統合した包括的なASDのFC異常の病態モデル確立を試み、特に年齢による病理変化のフローの解明を目指す。