The new approach for pulmonary arteriovenous fistula after Glenn surgery via shear stress and microRNA mediated mechanisms

Research Project

Project/Area Number	24K10955
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Review Section	Basic Section 52050:Embryonic medicine and pediatrics-related
Research Institution	Kagoshima University
Principal Investigator	川村順平鹿児島大学, 医歯学域医学系, 助教 (70838656)
Project Period (FY)	2024-04-01 – 2027-03-31
Project Status	Granted (Fiscal Year 2024)
Budget Amount *help	¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000) Fiscal Year 2026: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000) Fiscal Year 2025: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000) Fiscal Year 2024: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords	肺動静脈瘻
Outline of Research at the Start	肺動静脈瘻 (Pulmonary Arteriovenous Malformations: PAVMs) は、低酸素血症を引き起こす致死的な合併症であり、単心室症のGlenn手術後に発生したPAVMs (G-PAVMs) は深刻な問題である。Glenn手術後の解剖学的特徴を踏まえ、shear stressやその他のKLF2上流の制御因子を調節することでG-PAVMsの予防や治療へ発展することを明らかにする。