HECW2によるHBVウイルス複製維持機構の解明と抗HBV治療に向けた研究

• Project/Area Number: 24K11086
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 53010:Gastroenterology-related
• Research Institution: Kanazawa University
• Principal Investigator: 李 影奕 金沢大学, 医学系, 博士研究員 (70401940)
• Co-Investigator(Kenkyū-buntansha): 本多 政夫 金沢大学, 保健学系, 教授 (00272980)
• Project Period (FY): 2024-04-01 – 2027-03-31
• Project Status: Granted (Fiscal Year 2024)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2026: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2025: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2024: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: HBV persistance / HCEW2 / ubiquitination

Outline of Research at the Start

In this research project, we aim to elucidate the mechanisms underlying the impact of HECW2 on the persistence of HBV DNA both in vitro and in vivo. We will provide new insights into the development of novel antiviral therapeutics to cure hepatitis B.