Effects of endoscopic treatment of gastroesophageal reflux disease on organisms including intestinal microflora after termination of PPI/PCAB administration.

Research Project

Project/Area Number	24K11148
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Review Section	Basic Section 53010:Gastroenterology-related
Research Institution	Kanazawa University
Principal Investigator	鷹取元金沢大学, 附属病院, 准教授 (60613734)
Co-Investigator(Kenkyū-buntansha)	飯田宗穂金沢大学, 附属病院, 講師 (40705604)
Project Period (FY)	2024-04-01 – 2027-03-31
Project Status	Granted (Fiscal Year 2024)
Budget Amount *help	¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000) Fiscal Year 2026: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2025: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000) Fiscal Year 2024: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords	逆流性食道炎 / 内視鏡的逆流防止粘膜切除術 / 食道裂孔ヘルニア / 腸内細菌叢 / 酸分泌抑制薬
Outline of Research at the Start	(a)内視鏡的逆流防止粘膜切除術(ARMS)による治療 (b)腸管透過性試験（L/M比試験）による患者での腸内環境評価 (c)便検査（細菌叢解析と便中プロテアーゼによる腸内環境評価） (d)無菌マウスへの便細菌叢移植　　(e)PAR2欠損マウスにおける腸管透過性測定