Improving Functional Regeneration and Engraftment of Cardiomyocytes Derived from Human Induced Pluripotent Stem Cells by Brief Cycles of Transient Reprogramming

Research Project

Project/Area Number	24K11267
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Review Section	Basic Section 53020:Cardiology-related
Research Institution	Osaka University
Principal Investigator	Lucena.Cacace Antonio 大阪大学, ヒューマン・メタバース疾患研究拠点, 特任准教授(常勤) (60832748)
Project Period (FY)	2024-04-01 – 2027-03-31
Project Status	Granted (Fiscal Year 2024)
Budget Amount *help	¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000) Fiscal Year 2026: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2025: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000) Fiscal Year 2024: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords	hiPSC-CMs / Cell Cycle / Reprogramming / Regeneration / Cardiology
Outline of Research at the Start	The clarified mechanism and cardiac bioengineering will elucidate the cellular signaling regulated by OSKM on cardiomyocyte cell cycle reactivation, thus driving a better understanding of the fundamental biology behind cardiac regeneration and cellular engraftment.