Elucidation of the pathogenesis of pulmonary fibrosis and development of novel therapies targeting NAMPT

• Project/Area Number: 24K11312
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 53030:Respiratory medicine-related
• Research Institution: Hamamatsu University School of Medicine
• Principal Investigator: 穗積 宏尚 浜松医科大学, 医学部, 助教 (40771457)
• Co-Investigator(Kenkyū-buntansha): 須田 隆文 浜松医科大学, 医学部, 理事 (30291397)
• Project Period (FY): 2024-04-01 – 2027-03-31
• Project Status: Granted (Fiscal Year 2024)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2026: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2025: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2024: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 肺線維症 / NAMPT / ニコチナミドホスホリボシルトランスフェラーゼ

Outline of Research at the Start

肺線維症におけるNAMPTの役割と治療標的としての有用性を検討するため，次の研究を行う．
1.BLMマウスモデルにおけるNAMPT発現の評価．
2.肺線維芽細胞に対するNAMPTの機能解析．
3.BLMマウスモデルにおける抗NAMPT中和抗体の治療効果の検討．