Can non-anesthetic effects of ketamine improve outcome of patients with cancer surgery?

• Project/Area Number: 24K12064
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 55050:Anesthesiology-related
• Research Institution: Hirosaki University
• Principal Investigator: 丹羽 英智 弘前大学, 医学研究科, 准教授 (20374845)
• Project Period (FY): 2024-04-01 – 2029-03-31
• Project Status: Granted (Fiscal Year 2024)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2028: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2027: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2026: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2025: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2024: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
• Keywords: natural killer cell / 細胞傷害性 / レミフェンタニル / オピオイド

Outline of Research at the Start

本研究では、①基礎実験系で麻薬性鎮痛薬の抗癌免疫抑制作用の機序を解明しつつ、同時にこれをケタミンが打ち消すかを証明し、②臨床試験で麻薬性鎮痛薬とケタミンを併用した全身麻酔法が癌切除手術を受けた患者の生存率を改善するか、を検討する。