The research related to the establishment of novel tumor markers for head and neck cancer

Research Project

Project/Area Number	24K12736
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Review Section	Basic Section 56050:Otorhinolaryngology-related
Research Institution	Kindai University
Principal Investigator	若崎高裕近畿大学, 医学部, 講師 (10608871)
Co-Investigator(Kenkyū-buntansha)	神武洋二郎近畿大学, 産業理工学部, 教授 (90531963)
Project Period (FY)	2024-04-01 – 2027-03-31
Project Status	Granted (Fiscal Year 2024)
Budget Amount *help	¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000) Fiscal Year 2026: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2025: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2024: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords	頭頸部癌 / 腫瘍マーカー / lncRNA
Outline of Research at the Start	がん進展に重要と考えられるlncRNAに注目した。癌抑制に重要なINK4遺伝子座から転写される新規lncRNA ANROC(associated negative regulation of cell proliferation)および、がん促進lncRNAであるOIP5-AS1（OPA-interacting protein 5 antisense transcript 1）関して臨床的意義の解析を行う。①頭頸部癌の腫瘍マーカーおよび治療ターゲットとして有用性の有無の検証　②頭頸部癌での作用機序解析を行う。