Elucidating molecular mechanisms of the water-induced swallowing reflex under non-thirsty and thirsty conditions: the importance of TRPV4

• Project/Area Number: 24K12880
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 57010:Oral biological science-related
• Research Institution: Matsumoto Dental University
• Principal Investigator: Hossain M.Zakir 松本歯科大学, 歯学部, 講師 (40792445)
• Co-Investigator(Kenkyū-buntansha): 安藤 宏 松本歯科大学, 歯学部, 准教授 (30312094) ; 北川 純一 松本歯科大学, 歯学部, 教授 (50373006) ; Roy RitaRani 松本歯科大学, 歯学部, 助教 (70963487)
• Project Period (FY): 2024-04-01 – 2028-03-31
• Project Status: Granted (Fiscal Year 2024)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2027: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2026: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2025: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2024: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: Swallowing Reflex / TRPV4

Outline of Research at the Start

Difficulty in water swallowing is a significant health problem among patients with dysphagia. Exploring molecular mechanisms of water-induced swallowing may help to develop therapeutics for that problem. This study will explore the crucial roles of TRPV4 in water-induced swallowing.