| Project/Area Number |
24K13116
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 57060:Surgical dentistry-related
|
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| Research Institution | Kagoshima University |
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Principal Investigator |
NGUYEN THAO 鹿児島大学, 医歯学域歯学系, 助教 (40733837)
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| Co-Investigator(Kenkyū-buntansha) |
加治屋 由佳 鹿児島大学, 医歯学総合研究科, 技術職員 (30979589)
笹平 智則 鹿児島大学, 医歯学域歯学系, 教授 (90405374)
|
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| Project Period (FY) |
2024-04-01 – 2027-03-31
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| Project Status |
Granted (Fiscal Year 2024)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2026: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2025: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2024: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | head and neck cancer / lymphocytes / KPNA7 / E2F1 / c-jun |
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| Outline of Research at the Start |
This application seeks to understand the functional roles of KPNA7 amplification in HNSCC. Our hypothesis is KPNA7 promotes tumor formation and progession by enhancing importin-dependent nuclear transport of key oncogenic (E2F1, c-jun, and co-REST) transcription factors, which results in the increase of cancer cell growth, metastasis and the decrease of tumor-infiltrating lymphocytes
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