Evaluation of the effects of prior COVID-19-induced immunities on the development of severe dengue fever

• Project/Area Number: 24K13414
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 58020:Hygiene and public health-related: including laboratory approach
• Research Institution: Oita University
• Principal Investigator: カーン シャキル 大分大学, グローカル感染症研究センター, 講師 (70746867)
• Project Period (FY): 2024-04-01 – 2027-03-31
• Project Status: Granted (Fiscal Year 2024)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2026: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000); Fiscal Year 2025: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2024: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: Dengue fever / COVID-19 / Immune complexity / Severe dengue

Outline of Research at the Start

Since the 2nd year of the COVID-19 pandemic, an increased number of severe dengue fever (DF) cases have been recorded in many countries including Bangladesh. Whether prior COVID-19 interferes with developing severe DF is an unanswered question. With these realities, this study will assess the impacts of prior SARS-CoV-2 infection in the development of severe DF using large-scale clinical data obtained from DF patients in Bangladesh and subsequently performing laboratory experiments in Japan.