Assessment of dynamic movement and transfection efficiency of mRNA lipid nanoparticles in human iPSC-derived cornea-on-a-chip

• Project/Area Number: 24K15712
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 90110:Biomedical engineering-related
• Research Institution: Ritsumeikan University
• Principal Investigator: ABDALKADER Rodi 立命館大学, 立命館グローバル・イノベーション研究機構, 准教授 (20839964)
• Project Period (FY): 2024-04-01 – 2027-03-31
• Project Status: Granted (Fiscal Year 2024)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2026: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2025: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2024: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: Cornea-on-a-chip / iPSC / mRNA-LNPs

Outline of Research at the Start

This research aims to investigate the dynamic movement and transfection efficiency of messenger RNA lipid nanoparticles (mRNA-LNPs) in the human cornea-on-a-chip using an interdisciplinary approach that combines microfluidics technologies, stem cells, and nanotechnology.