A methodology to connect functionalized gonadal constructs to a chick embryo through mechanically induced blood vessels from an egg

Research Project

Project/Area Number	24K15741
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Review Section	Basic Section 90110:Biomedical engineering-related
Research Institution	Kindai University Technical College
Principal Investigator	黄文敬近畿大学工業高等専門学校, 総合システム工学科制御情報コース, 准教授 (00633413)
Project Period (FY)	2024-04-01 – 2027-03-31
Project Status	Granted (Fiscal Year 2024)
Budget Amount *help	¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000) Fiscal Year 2026: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000) Fiscal Year 2025: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000) Fiscal Year 2024: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords	effects of opposite sex / Induced blood vessel / Change of sex hormone / Sex differentiation
Outline of Research at the Start	The applicant will induce blood vessels from the chick chorioallantoic membrane to the semi-closed chambers on the artificial eggshell of a chick embryo. Gonadal constructs with blood vessel penetration will be built in the semi-closed chambers by using gonadal cells from donor chick embryos.