Development of a novel oral vaccine for fish: Synergy of chitosan nano particle and complement-mediated opsonization

Research Project

Project/Area Number	24K17960
Research Category	Grant-in-Aid for Early-Career Scientists
Allocation Type	Multi-year Fund
Review Section	Basic Section 40040:Aquatic life science-related
Research Institution	Kyushu University
Principal Investigator	KIZHAKKUMPAT AKHIL 九州大学, 農学研究院, 学術研究員 (60991601)
Project Period (FY)	2024-04-01 – 2027-03-31
Project Status	Granted (Fiscal Year 2024)
Budget Amount *help	¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000) Fiscal Year 2026: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000) Fiscal Year 2025: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000) Fiscal Year 2024: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords	Oral fish Vaccine / Chitosan nanoparticle / Complement protein
Outline of Research at the Start	The current study proposes utilizing chitosan nanoparticle tagged with the complement protein C3b as a drug delivery vehicle for oral fish vaccines. The encapsulation of the vaccine in chitosan nanoparticle protects the antigen from getting degraded and C3b enhances the opsonization of the vaccine.