| Project/Area Number |
24K18002
|
|---|
| Research Category |
Grant-in-Aid for Early-Career Scientists
|
| Allocation Type | Multi-year Fund |
|---|
| Review Section |
Basic Section 42010:Animal production science-related
|
|---|
| Research Institution | Tokyo University of Agriculture and Technology |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2024-04-01 – 2026-03-31
|
| Project Status |
Granted (Fiscal Year 2024)
|
| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2025: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2024: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
|---|
| Keywords | oocyte / vitrification / cryoprotectant / gamete preservation / graphene oxide |
|---|
| Outline of Research at the Start |
To improve the success of oocyte cryopreservation, I propose using graphene oxide dually functionalized with antioxidant and cryoprotectant molecules (DF-GOs). These enhanced GOs are expected to improve the thermal conductivity during the freezing and thawing stages, serve as ROS capturing agents that will protect the oocytes from oxidative stress damage and prevent the formation of water ice crystals. By using these new materials, it is expected that high quality oocytes will be obtained and the success of ART treatments involving cryopreservation will be significantly increased.
|
