Structural and Functional Analysis of Motor Protein-Powered Intraflagellar Transport

• Project/Area Number: 24K18106
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 44010:Cell biology-related
• Research Institution: The University of Tokyo
• Principal Investigator: JIANG XUGUANG 東京大学, 大学院医学系研究科(医学部), 特任助教 (20992639)
• Project Period (FY): 2024-04-01 – 2027-03-31
• Project Status: Granted (Fiscal Year 2024)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2026: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2025: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2024: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: Cilia / Kinesin / Motor Protein / Ciliogenesis / Intraflagellar Transport

Outline of Research at the Start

This project seeks to provide a more precise ciliary anterograde transport model of motor protein-IFT machinery via genetic manipulation, cryoEM structural analysis and biochemical validation, and thus to clarify the underlying molecular mechanisms with functional studies.