| Project/Area Number |
24K18291
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 47040:Pharmacology-related
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| Research Institution | Fujita Health University |
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Principal Investigator |
張 心健 藤田医科大学, 精神・神経病態解明センター, 助教 (10850430)
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| Project Period (FY) |
2024-04-01 – 2026-03-31
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| Project Status |
Granted (Fiscal Year 2024)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2025: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2024: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | drug addiction / potassium channels / nucleus accumbens / medium spiny neurons / neuronal excitability |
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| Outline of Research at the Start |
Although drug addiction is a serious social problem, there is no effective solution, yet. Previously, we have analyzed intracellular dopamine signaling pathways in NAc and elucidated that dopamine increases neuronal excitability by targeting potassium channels to regulate rewarding behavior. In this study, I will manipulate the activity of potassium channel to examine its effect on addictive drug-associated memory. I will also elucidate the mechanism between potassium channel and reward memory, and screen useful potassium channel openers that may become potential therapy for drug addiction.
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