Role of Ubiquitin-mediated Immunity and Autophagy Control in Chronic Gut Inflammation

Research Project

Project/Area Number	24K18379
Research Category	Grant-in-Aid for Early-Career Scientists
Allocation Type	Multi-year Fund
Review Section	Basic Section 49010:Pathological biochemistry-related
Research Institution	Osaka University
Principal Investigator	Kaypee StephanieRoshni 大阪大学, 大学院生命機能研究科, 特任研究員(常勤) (40978863)
Project Period (FY)	2024-04-01 – 2026-03-31
Project Status	Granted (Fiscal Year 2024)
Budget Amount *help	¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000) Fiscal Year 2025: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000) Fiscal Year 2024: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords	Ubiquitin / Crohn's disease / Inflammation / E3 ligase / Gut inflammation
Outline of Research at the Start	Dysregulated immune pathways lead to hyperinflammation-related disorders like Crohn’s disease (CD). The ubiquitin ligase XIAP is implicated in CD. Our study investigates its role in autophagy and immunity in CD and assess disease-causing XIAP mutants and substrates for more effective treatment.